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Hypolipidemic Activity Hesperidin can inhibit the activity of 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase), a key enzyme involved in cholesterol biosynthesis

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Addition of a triphenylphosphonium group facilitates the collection of O 2 − in the mitochondria, while the reaction of mitoSOX with O 2 − produces 2-hydroxy-mito-ethidium, which can be measured with high performance-liquid chromatography (HPLC) [82,83,84]